Mango phenolics increase serum apolipoprotein A1/B ratio in rats fed high cholesterol and sodium cholate diets
ABSTRACT: BACKGROUND: Serum lipoproteins are in dynamic equilibrium, partially controlled by the apolipoprotein A1 to apolipoprotein B ratio (APOA1/APOB). Freeze-dried mango pulp (FDM) is a rich source of phenolic compounds (MP) and dietary fiber (MF), although their effects on lipoprotein metabol...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , |
| Format: | Artículo |
| Language: | en_US |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jsfa.9340 https://onlinelibrary.wiley.com/doi/full/10.1002/jsfa.9340 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | ABSTRACT: BACKGROUND: Serum lipoproteins are in dynamic equilibrium, partially controlled by the apolipoprotein A1 to
apolipoprotein B ratio (APOA1/APOB). Freeze-dried mango pulp (FDM) is a rich source of phenolic compounds (MP) and dietary
fiber (MF), although their effects on lipoprotein metabolism have not yet been studied.
RESULTS: Thirty male Wistar rats were fed with four different isocaloric diets (3.4 kcal g−1) for 12weeks: control diet, high
cholesterol (8 g kg−1) + sodium cholate (2 g kg−1) diet either alone or supplemented with MF (60 g kg−1), MP (1 g kg−1) or FDM
(50 g kg−1). MP and FDMreduced food intake,whereas MF andMP tended to increase serum APOA1/APOB ratio, independently
of their hepatic gene expression. This suggests that lipoprotein metabolismwas favorably altered by mango bioactives,MP also
mitigated the non-alcoholic steatohepatitis that resulted fromthe intake of this diet.
CONCLUSION: We propose that phenolics are the most bioactive components of mango pulp, acting as anti-atherogenic
and hepatoprotective agents, with a mechanism of action tentatively based on changes to the main protein components
of lipoproteins. |
|---|