In vitro gastrointestinal digestion and simulated colonic fermentation of pistachio nuts determine bioaccesibility and biosynthesis of chronobiotics
Chronodisruption leads to obesity and other metabolic disorders that can be alleviated by food-derived potential chronobiotics, such as phytomelatonin (PMT), phenolic compounds (PCs) and dietary fiber rich pistachios. Pistachios with (PN + SC) or without (PN) the seed coat were investigated for th...
Saved in:
| Andre forfattere: | , , , |
|---|---|
| Format: | Artículo |
| Sprog: | en_US |
| Udgivet: |
2021
|
| Fag: | |
| Online adgang: | https://doi.org/10.1039/D0FO02708A https://pubs.rsc.org/en/content/articlelanding/2021/fo/d0fo02708a |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|
| Summary: | Chronodisruption leads to obesity and other metabolic disorders that can be alleviated by food-derived
potential chronobiotics, such as phytomelatonin (PMT), phenolic compounds (PCs) and dietary fiber rich
pistachios. Pistachios with (PN + SC) or without (PN) the seed coat were investigated for their in vitro
chronobiotic potential since they are one of the main reported PMT sources. Consequently we evaluated
the bioaccessibility, permeability, and biosynthesis of pistachio chronobiotics, particularly PMT, during
gastrointestinal and colonic fermentation. The maximum in vitro bioaccessibility and apparent permeability
(efflux-prone) of PCs, flavonoids and PMT were sample-specific [∼1.3% (both), 27 and 3.4% (PN
+ SC)], but additional amounts (flavonoids > PCs > PMT) were released under simulated colonic conditions.
Short-chain fatty acids (SCFAs; 38 mM; >50% butyrate, PN + SC > PN) and some metabolites (e.g.,
indole, benzaldehyde, phenolic acids, and aliphatic/aromatic hydrocarbons) were detected depending on
the sample. The predominant pistachio butyrate production during in vitro colonic fermentation can
improve chronodisruption and benefit obese individuals. Pistachio’s digestion increases the bioaccessibility
and intestinal permeability of potential chronobiotics (PMT and PCs) and the biosynthesis of colonic
metabolites (SCFAs, among others) also with chronobiotic potential. |
|---|