Tratamiento farmacológico de aneurismas de la aorta abdominal
Abdominal aortic aneurysm (aaa) is a progressive dilation located in the abdominal aorta that is associated with a high mortality rate. The pathophysiology is complex because it involves mechanisms that culminate in a destruction of the middle layer from the aorta, loss of collagen fibers, and an in...
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| Language: | spa |
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Universidad Autónoma de Ciudad Juárez
2021
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| Online Access: | http://erevistas.uacj.mx/ojs/index.php/expemed/article/view/4560 |
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| Summary: | Abdominal aortic aneurysm (aaa) is a progressive dilation located in the abdominal aorta that is associated with a high mortality rate. The pathophysiology is complex because it involves mechanisms that culminate in a destruction of the middle layer from the aorta, loss of collagen fibers, and an inflammatory infiltrate that further aggravates the process. It is necessary to develop a pharmacological treatment that demonstrates prevention of the expansion and, therefore, the rupture of the aaa. Currently, there are some drugs which have shown to be beneficial; however, there is not enough evidence to prove their effectiveness. Research on the molecular mechanisms of its pathophysiology has allowed the development of novel drugs with promising results in animal models; however, it is necessary to expand research on these new therapeutic targets. |
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