Influence of serum leptin levels and Q223R leptin receptor polymorphism on clinical characteristic of patients with rheumatoid arthritis from Western Mexico
Objective The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico. Methods A cross-sectional study was performed with 70 RA...
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Other Authors: | , , , , , , , , |
Format: | Artículo |
Language: | en_US |
Published: |
2018
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Subjects: | |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949616/ |
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Summary: | Objective
The aim of the present study was to evaluate the possible
association between the Q223R Leptin receptor
(LEPR) polymorphism (A>G; rs1137101) and leptin
levels in patients with rheumatoid arthritis (RA) from
Western Mexico.
Methods
A cross-sectional study was performed with 70 RA patients
and 74 controls subject (CS). Disease activity was
evaluated using DAS28 score, the Q223R LEPR polymorphism
was determined by the Polymerase Chain
Reaction-Restriction Fragment Length Polymorphism
(PCR-RFLP) and serum leptin levels, erythrocyte sedimentation
rate (ESR), C-reactive protein (CRP) and
rheumatoid factor (RF) were quantified.
Results
RA patients had significant high serum leptin
levels compared with CS; leptin levels correlated
strongly with body composition measures,
but not with inflammatory markers, disease
evolution, and activity. The genotype and allele
frequencies of the Q223R LEPR polymorphism
were not associated with RA. Similarly,
leptin levels did not differ between Q223R
LEPR genotypes.
Conclusion
The LEPR Q223R polymorphism was not associated
with RA risk in patients from Mexican
population, even though high levels of serum
leptin were present and these could explain the
low weight observed in RA patients when they
were compared to control subjects. However,
the serum leptin levels did not correlate with
inflammatory markers, severity and disease
evolution. |
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