Expression of E‑cadherin, syndecan 1, Ki‑67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy
Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, i...
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| Other Authors: | , , , |
| Format: | Artículo |
| Language: | en_US |
| Published: |
2018
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| Online Access: | https://doi.org/10.4103/IJPM.IJPM_574_17. https://www.ncbi.nlm.nih.gov/pubmed/?term=Expression+of+E%E2%80%91cadherin%2C+syndecan+1%2C+Ki%E2%80%9167%2C+and+maintenance+minichromosome+3+in+tissue+lesions+of+actinic+prurigo+obtained+by+incisional+biopsy https://www.ncbi.nlm.nih.gov/pubmed/?term=Expression+of+E%E2%80%91cadherin%2C+syndecan+1%2C+Ki%E2%80%9167%2C+and+maintenance+minichromosome+3+in+tissue+lesions+of+actinic+prurigo+obtained+by+incisional+biopsy |
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| Summary: | Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained lymphoid follicles (Ki 67: epidermis [17.7% ± 6.79%] and dermis [7.73% ± 6.69%]; MCM3: epidermis [22.92% ± 10.12%] and dermis [6.13% ± 6.27%]). In conclusión AP is a disease in which there is no evidence that the lesions are potentially cancerous. AP cheilitis should not be confused with actinic cheilitis because they are separate entities. |
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