Influence of serum leptin levels and Q223R leptin receptor polymorphism on clinical characteristic of patients with rheumatoid arthritis from Western Mexico

Influence of serum leptin levels and Q223R leptin receptor polymorphism on clinical characteristic of patients with rheumatoid arthritis from Western Mexico

Objective The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico. Methods A cross-sectional study was performed with 70 RA patien...

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Bibliographic Details
Main Author: Angel-Chávez, Luis Ignacio
Other Authors: Ruelas-Cinco, Elizabeth, Hernández-Bello, Jorge, Castro, Elena, Vázquez-Villamar, Mirna, Parra-Rojas, Isela, Brennan-Bourdon, L. Michele, Muñoz-Barrios, Salvador, Guerrero-Velázquez, Celia, Muñoz-Valle, José Francisco
Format: Artículo
Language:English
Published: 2018
Subjects:
leptin receptor
rheumatoid arthritis
leptin
polymorphism
Research Subject Categories::MEDICINE
info:eu-repo/classification/cti/3
Online Access:http://www.ifcc.org/media/477263/ejifcc2018vol29no1pp026-035.pdf
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Summary:Objective The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico. Methods A cross-sectional study was performed with 70 RA patients and 74 controls subject (CS). Disease activity was evaluated using DAS28 score, the Q223R LEPR polymorphism was determined by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and serum leptin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF) were quantified.

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