In vitro cytotoxic activity of bark extracts from Pinus durangensis Martinez and Quercus sideroxyla Bonpl.
Nowadays, plants bioactive compounds represent a great potential for discovering novel drugs that could act in cancer treatment. Previous word reports that different pine and oak species possess cytotoxic activities against various cancer cell lines. The present study evaluated the phenolic pro...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , |
| Format: | Artículo |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://doi.org/10.18633/biotecnia.v24i1.1520 https://www.scielo.org.mx/scielo.php?pid=S1665-14562022000100055&script=sci_arttext |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Nowadays, plants bioactive compounds represent a
great potential for discovering novel drugs that could act in
cancer treatment. Previous word reports that different pine
and oak species possess cytotoxic activities against various
cancer cell lines. The present study evaluated the phenolic
profile and cytotoxic activities of crude and organic extracts
from P. durangensis and Q. sideroxyla bark. Among ESI-MS
identified compounds in extracts from both species, are
taxifolin and procyanidin dimers. The cytotoxic activity was
performed on MDA-MB-231 (breast cancer), HeLa (cervix
cancer), MCF-10A (breast non-tumorous cell), and HSF-1184
(human skin fibroblast cells) by MTT assay. All extracts showed
a dose-dependent cytotoxic effect against cancer cell lines
and small or no activity against the non-tumorous cells. The
results provide important information about the cytotoxic
activity of bark extracts from P. durangensis and Q. sideroxyla.
This strong cytotoxic effect represents an opportunity for the
valorization of a by-product of the wood industry.
Keywords: Bark extracts, cytotoxicity, phenolic profile. |
|---|