Equine Herpesvirus-I Infection in Horses: Recent Updates on its Pathogenicity, Vaccination, and Preventive Management Strategies.
Equine herpesvirus-1 (EHV-1) is one of the most common and ubiquitous viral pathogens infecting equines, particularly horses worldwide. The EHV-1 is known to induce not only humoral but also cellular immune responses in horses. Respiratory distress, abortion in pregnant mares, neurological disorde...
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| Формат: | Artículo |
| Язык: | en_US |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://doi.org/10.1016/j.jevs.2020.102923 https://www.j-evs.com |
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| Итог: | Equine herpesvirus-1 (EHV-1) is one of the most common and ubiquitous viral pathogens infecting
equines, particularly horses worldwide. The EHV-1 is known to induce not only humoral but also cellular
immune responses in horses. Respiratory distress, abortion in pregnant mares, neurological disorders,
and neonatal foal deaths represent EHV-1 infection. Despite the limited success of inactivated, subunit,
live, and DNA vaccines, over the past few decades, vaccination remains the prime preventive option to
combat EHV-1 infection in horses. However, current vaccines lack the potentiality to protect the
neurological form of infections in horses. There is desperate necessity to search effectual EHV-1 vaccines
that may stimulate not only mucosal and systemic cellular immunity but also humoral immunity in the
horses. This review highlights the state of knowledge regarding EHV-1 biology, EHV-1 pathogenesis, and
disparate vaccines studied in the past to prevent EHV-1 infection. The review also underlines the best
management strategies which certainly need to be adopted by veterinarians in order to avoid and
prevent EHV-1 infection and outbreak in horses in the future. |
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